Introduction: Osteoarthritis trials usually report average changes in visual analogue scale (VAS) pain, and examine the difference between treatment and placebo. We investigated whether dichotomous responder analysis provides a more informative interpretation of drug efficacy. Methods: Merck supplied the number of patients who, by 6 weeks, had achieved pain relief compared with a baseline of 0% or more, 10% or more, 20% or more, and so on at equal intervals up to 90% or more. These different ...Expand abstract
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- Citation: Moore, R. A. et al. (2008). 'Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores', Arthritis Research & Therapy, 10(2), R39. [Available at http://arthritis-research.com/content/10/2/R39]. Copyright 2008 Moore et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores
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