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Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores

Abstract:

Introduction: Osteoarthritis trials usually report average changes in visual analogue scale (VAS) pain, and examine the difference between treatment and placebo. We investigated whether dichotomous responder analysis provides a more informative interpretation of drug efficacy. Methods: Merck supplied the number of patients who, by 6 weeks, had achieved pain relief compared with a baseline of 0% or more, 10% or more, 20% or more, and so on at equal intervals up to 90% or more. These different ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/ar2394

Authors


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Institution:
University of Oxford
Research group:
Pain Research
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Anaesthetics
Role:
Author
More by this author
Institution:
"Musgrove Park Hospital, Belfast"
Department:
Department of Rheumatology
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Pain Research
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Anaesthetics
Role:
Author
More by this author
Institution:
University of Oxford
Research group:
Pain Research
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Anaesthetics
Role:
Author
Oxford Pain Research Trust More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Arthritis Research & Therapy Journal website
Volume:
10
Issue:
2
Pages:
Article: R39
Publication date:
2008-04-05
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:664c058c-c0ed-4373-9a43-fa3b8cfddc5d
Local pid:
ora:2395
Language:
English
Keywords:
Subjects:

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