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Journal article

Stress-activated kinase MKK7 governs epigenetics of cardiac repolarization for arrhythmia prevention

Abstract:

BACKGROUND: -Ventricular arrhythmia is a leading cause of cardiac mortality. Most antiarrhythmics present paradoxical pro-arrhythmic side effects, culminating in a greater risk of sudden death. METHODS: -We describe a new regulatory mechanism linking mitogen-activated kinase kinase-7 (MKK7) deficiency with increased arrhythmia vulnerability in hypertrophied and failing hearts using mouse models harbouring MKK7 knockout or overexpression. The human relevance of this arrhythmogenic mechanism is...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1161/CIRCULATIONAHA.116.022941

Authors


Chowdhury, SK More by this author
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Grant:
PG/09/052/27833, PG/12/76/29852 and FS/15/16/31477
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Grant:
National Scientist Development grants (12SDG12070077 to X. Liao)
Publisher:
American Heart Association Publisher's website
Journal:
Circulation Journal website
Volume:
135
Issue:
7
Pages:
683-699
Publication date:
2016-11-29
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Pubs id:
pubs:664000
URN:
uri:662e21c5-37f6-4531-b9b7-7e2a93e2ae59
UUID:
uuid:662e21c5-37f6-4531-b9b7-7e2a93e2ae59
Local pid:
pubs:664000
Paper number:
7

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