- Abstract:
-
BACKGROUND: -Ventricular arrhythmia is a leading cause of cardiac mortality. Most antiarrhythmics present paradoxical pro-arrhythmic side effects, culminating in a greater risk of sudden death. METHODS: -We describe a new regulatory mechanism linking mitogen-activated kinase kinase-7 (MKK7) deficiency with increased arrhythmia vulnerability in hypertrophied and failing hearts using mouse models harbouring MKK7 knockout or overexpression. The human relevance of this arrhythmogenic mechanism is...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 4.2mb)
-
- Publisher copy:
- 10.1161/CIRCULATIONAHA.116.022941
-
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- Grant:
- PG/09/052/27833, PG/12/76/29852 and FS/15/16/31477
- Grant:
- National Scientist Development grants (12SDG12070077 to X. Liao)
- Publisher:
- American Heart Association Publisher's website
- Journal:
- Circulation Journal website
- Volume:
- 135
- Issue:
- 7
- Pages:
- 683-699
- Publication date:
- 2016-11-29
- DOI:
- EISSN:
-
1524-4539
- ISSN:
-
0009-7322
- Pubs id:
-
pubs:664000
- URN:
-
uri:662e21c5-37f6-4531-b9b7-7e2a93e2ae59
- UUID:
-
uuid:662e21c5-37f6-4531-b9b7-7e2a93e2ae59
- Local pid:
- pubs:664000
- Paper number:
- 7
- Language:
- English
- Keywords:
- Copyright holder:
- American Heart Association, Inc.
- Copyright date:
- 2016
- Notes:
-
Copyright © 2016 American Heart Association, Inc. This is the accepted manuscript version of the article. The final version is available online from American Heart Association at: https://doi.org/10.1161/CIRCULATIONAHA.116.022941
Journal article
Stress-activated kinase MKK7 governs epigenetics of cardiac repolarization for arrhythmia prevention
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