Journal article
Stress-activated kinase MKK7 governs epigenetics of cardiac repolarization for arrhythmia prevention
- Abstract:
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BACKGROUND: -Ventricular arrhythmia is a leading cause of cardiac mortality. Most antiarrhythmics present paradoxical pro-arrhythmic side effects, culminating in a greater risk of sudden death. METHODS: -We describe a new regulatory mechanism linking mitogen-activated kinase kinase-7 (MKK7) deficiency with increased arrhythmia vulnerability in hypertrophied and failing hearts using mouse models harbouring MKK7 knockout or overexpression. The human relevance of this arrhythmogenic mechanism is...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
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(Accepted manuscript, pdf, 4.2MB)
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- Publisher copy:
- 10.1161/CIRCULATIONAHA.116.022941
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Authors
Funding
+ British Heart Foundation
More from this funder
Grant:
PG/09/052/27833,PG/12/76/29852
FS/15/16/31477
+ American Heart Association
More from this funder
Grant:
National Scientist Development grants (12SDG12070077 to X. Liao
Bibliographic Details
- Publisher:
- American Heart Association Publisher's website
- Journal:
- Circulation Journal website
- Volume:
- 135
- Issue:
- 7
- Pages:
- 683-699
- Publication date:
- 2016-11-29
- Acceptance date:
- 2016-11-16
- DOI:
- EISSN:
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1524-4539
- ISSN:
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0009-7322
- Source identifiers:
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664000
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:664000
- UUID:
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uuid:662e21c5-37f6-4531-b9b7-7e2a93e2ae59
- Local pid:
- pubs:664000
- Deposit date:
- 2016-12-08
Terms of use
- Copyright holder:
- American Heart Association, Inc
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 American Heart Association, Inc. This is the accepted manuscript version of the article. The final version is available online from American Heart Association at: https://doi.org/10.1161/CIRCULATIONAHA.116.022941
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