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Animal models of epigenetic regulation in neuropsychiatric disorders.

Abstract:

Epigenetics describes the phenomenon of heritable changes in gene regulation that are governed by non-Mendelian processes, primarily through biochemical modifications to chromatin structure that occur during cell development and differentiation. Numerous lines of evidence link abnormal levels of chromatin modifications (either to DNA, histones, or both) in patients with a wide variety of diseases including cancer, psychiatry, neurodegeneration, metabolic and inflammatory disorders. Drugs that...

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Publisher copy:
10.1007/7854_2010_104

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Current topics in behavioral neurosciences More from this journal
Volume:
7
Issue:
1
Pages:
281-322
Publication date:
2011-01-01
DOI:
EISSN:
1866-3389
ISSN:
1866-3370
Language:
English
Keywords:
Pubs id:
pubs:112511
UUID:
uuid:662d3b1e-57ab-4131-a570-f917b512d198
Local pid:
pubs:112511
Source identifiers:
112511
Deposit date:
2012-12-19

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