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MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.

Abstract:

Radical radiotherapy and surgery achieve similar cure rates in muscle-invasive bladder cancer, but the choice of which treatment would be most beneficial cannot currently be predicted for individual patients. The primary aim of this study was to assess whether expression of any of a panel of DNA damage signaling proteins in tumor samples taken before irradiation could be used as a predictive marker of radiotherapy response, or rather was prognostic. Protein expression of MRE11, RAD50, NBS1, A...

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Publication status:
Published

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Authors


Choudhury, A More by this author
Nelson, LD More by this author
Bhattarai, S More by this author
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Journal:
Cancer research
Volume:
70
Issue:
18
Pages:
7017-7026
Publication date:
2010-09-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:6627d202-9b63-4bbe-bae9-c2c4881e1db0
Source identifiers:
130829
Local pid:
pubs:130829

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