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Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits.

Abstract:

BACKGROUND: Genetic studies have provided ample evidence of the influence of non-coding DNA polymorphisms on trait variance, particularly those occurring within transcription factor binding sites. Protein binding microarrays and other platforms that can map these sites with great precision have enhanced our understanding of how a single nucleotide polymorphism can alter binding potential within an in vitro setting, allowing for greater predictive capability of its effect on a transcription fa...

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Publication status:
Published

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Publisher copy:
10.1186/gb-2011-12-7-r70

Authors


Teixeira, A More by this author
Oikonomopoulos, S More by this author
Humburg, P More by this author
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Journal:
Genome biology
Volume:
12
Issue:
7
Pages:
R70
Publication date:
2011
DOI:
EISSN:
1465-6914
ISSN:
1465-6906
URN:
uuid:6624c4e6-7b87-4f2a-8a7a-fbb8501fc1fb
Source identifiers:
167557
Local pid:
pubs:167557

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