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Structural characterization of a 2'F-RNA aptamer that binds a HIV-1 SU glycoprotein, gp120.

Abstract:

Here we describe the isolation of specific 2'F-substituted RNA ligands for the SU glycoprotein, gp120, of HIV-1 strain HXB2. These aptamers bind the target protein with an affinity of the order of 10(-7) M. Binding was specific to SU glycoprotein and directed to a non-neutralizing epitope that was not shared with the related strain, HIV-1(BaL). The structure of one aptamer was defined by a combination of deletion analysis and enzymatic probing studies, revealing a 42 nt minimal element compri...

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Publication status:
Published

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Journal:
Biochemical and biophysical research communications
Volume:
293
Issue:
3
Pages:
924-931
Publication date:
2002-05-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:6614ceb9-e64d-4d83-8359-dd86d7f08f83
Source identifiers:
3942
Local pid:
pubs:3942

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