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restrictive vs liberal blood transfusion for acute upper gastrointestinal bleeding: Rationale and protocol for a cluster randomized feasibility trial

Abstract:

Acute upper gastrointestinal bleeding (AUGIB) is the commonest reason for hospitalization with hemorrhage in the UK and the leading indication for transfusion of red blood cells (RBCs). Observational studies suggest an association between more liberal RBC transfusion and adverse patient outcomes, and a recent randomised trial reported increased further bleeding and mortality with a liberal transfusion policy. TRIGGER (Transfusion in Gastrointestinal Bleeding) is a pragmatic, cluster randomize...

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Publisher copy:
10.1016/j.tmrv.2013.04.001

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Journal:
Transfusion Medicine Reviews More from this journal
Volume:
27
Issue:
3
Pages:
146-153
Publication date:
2013-07-01
DOI:
EISSN:
1532-9496
ISSN:
0887-7963
Language:
English
Pubs id:
pubs:416836
UUID:
uuid:660ca259-9380-48bb-b967-b58805d3c300
Local pid:
pubs:416836
Source identifiers:
416836
Deposit date:
2013-11-16

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