restrictive vs liberal blood transfusion for acute upper gastrointestinal bleeding: Rationale and protocol for a cluster randomized feasibility trial

Journal article

Acute upper gastrointestinal bleeding (AUGIB) is the commonest reason for hospitalization with hemorrhage in the UK and the leading indication for transfusion of red blood cells (RBCs). Observational studies suggest an association between more liberal RBC transfusion and adverse patient outcomes, and a recent randomised trial reported increased further bleeding and mortality with a liberal transfusion policy. TRIGGER (Transfusion in Gastrointestinal Bleeding) is a pragmatic, cluster randomize...

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Authors: Jairath, V; Kahan, B; Gray, A; Doré, C; Mora, A

• Journal: Transfusion Medicine Reviews
• Volume: 27
• Issue: 3
• Pages: 146-153
• Publication date: 2013-07-01
• DOI: 10.1016/j.tmrv.2013.04.001
• EISSN: 1532-9496
• ISSN: 0887-7963
• Language: English