Vehicles for genetic vaccines against human immunodeficiency virus: induction of T cell-mediated immune responses.

Journal article

Success of a candidate vaccine against human immunodeficiency virus (HIV) depends on the type, site, strength, longevity and specificity of the immune responses it induces. The specificity of a vaccine is determined by the HIV-derived immunogens it employs in its formulation. Central to the other features is a correct and efficient delivery of the immunogens to the relevant cells of the immune system, which leads to orchestrated actions of millions of cells of several types and functions at m...

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Authors: Hanke, T

• Journal: Current molecular medicine
• Volume: 1
• Issue: 1
• Pages: 123-135
• Publication date: 2001-03-01
• DOI: 10.2174/1566524013364004
• EISSN: 1875-5666
• ISSN: 1566-5240
• Language: English
• Keywords: AIDS Vaccines; Lymphocyte Activation; HIV Infections; Cytotoxicity, Immunologic; Vaccines, DNA; Animals; Genetic Vectors; T-Lymphocytes; Humans; Plasmids