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Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13.

Abstract:

Severe falciparum malaria remains a major killer in tropical countries. Central in the pathophysiology is mechanical obstruction in the microcirculation caused by cytoadherence and sequestration of parasitized erythrocytes. However, the pathogenesis of many features complicating severe malaria, including coma, renal failure and thrombocytopenia, remains incompletely understood. These disease manifestations are also key features of thrombotic thrombocytopenic purpura, a life-threatening diseas...

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Publication status:
Published

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Publisher copy:
10.1160/th09-04-0223

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Journal:
Thrombosis and haemostasis
Volume:
103
Issue:
1
Pages:
181-187
Publication date:
2010-01-01
DOI:
ISSN:
0340-6245
Source identifiers:
45924

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