Thesis
TBK1- and IKKe-mediated control of NLRP3 inflammasome activation and regulation of cell death
- Abstract:
-
Macrophages are equipped with Pattern Recognition Receptors (PRR), such as Toll-like receptors, to detect pathogens or damage signals. Activation of PRRs results in the upregulation of pro-inflammatory cytokines and phagocytic activity to clear the infection but also in a pro-survival programme. If the infection is not cleared and the cell is compromised or invaded by pathogens, intracellular sensors of damage are activated. The NLRP3 inflammasome is one of these intracellular sensors of i...
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Authors
Contributors
+ Bezbradica Mirkovic, J
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
ORCID:
0000-0003-1441-1727
+ Midwood, K
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
Funding
+ Kennedy Trust for Rheumatology Research
More from this funder
Programme:
Kennedy Trust Prize Studentship
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- DOI:
Item Description
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2024-01-22
Terms of use
- Copyright holder:
- Fischer, FA
- Copyright date:
- 2023
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