Journal article
Transforming Growth Factor β drives haemogenic endothelium programming and the transition to haematopoietic stem cells
- Abstract:
-
Hematopoietic stem cells (HSCs) are self-renewing multipotent stem cells that generate mature blood lineages throughout life. They, together with hematopoietic progenitor cells (collectively known as HSPCs), emerge from hemogenic endothelium in the floor of the embryonic dorsal aorta by an endothelial-to-hematopoietic transition (EHT). Here we demonstrate that transforming growth factor β (TGFβ) is required for HSPC specification and that it regulates the expression of the Notch ligand Jagged...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ British Heart Foundation
More from this funder
Grant:
IBSR Fellowship FS/13/50/30436
CoRE Fellowship
PG/14/39/30865
Bibliographic Details
- Publisher:
- Cell Press
- Journal:
- Developmental Cell More from this journal
- Volume:
- 38
- Issue:
- 4
- Pages:
- 358–370
- Publication date:
- 2016-08-04
- Acceptance date:
- 2016-06-08
- EISSN:
-
1878-1551
- ISSN:
-
1534-5807
Item Description
Terms of use
- Copyright holder:
- Monteiro et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY 4.0 license. Open access funded by the British Heart Foundation.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record