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High-throughput structural biology of metabolic enzymes and its impact on human diseases.

Abstract:

The Structural Genomics Consortium (SGC) is a public-private partnership that aims to determine the three-dimensional structures of human proteins of medical relevance and place them into the public domain without restriction. To date, the Oxford Metabolic Enzyme Group at SGC has deposited the structures of more than 140 human metabolic enzymes from diverse protein families such as oxidoreductases, hydrolases, oxygenases and fatty acid transferases. A subset of our target proteins are involve...

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Authors


Yue, Wyatt W More by this author
Oppermann, Udo More by this author
Journal:
Journal of inherited metabolic disease
Volume:
34
Issue:
3
Pages:
575-581
Publication date:
2011
ISSN:
1573-2665
URN:
uuid:65ec9678-d6d4-4610-8e3d-1fbdb9eff3ac
Local pid:
SGC:21340633
Language:
English

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