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Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas

Abstract:

The recently described combined carbogen USPIO (CUSPIO) magnetic resonance imaging (MRI) method uses spatial correlations in independent imaging biomarkers to assess specific components of tumor vascular structure and function. Our study aimed to evaluate CUSPIO biomarkers for the assessment of tumor response to antiangiogenic therapy. CUSPIO imaging was performed in subcutaneous rat C6 gliomas before and 2 days after treatment with the potent VEGF-signaling inhibitor cediranib (n = 12), or v...

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Publisher copy:
10.1002/ijc.27460

Authors


Journal:
International Journal of Cancer
Volume:
131
Issue:
8
Pages:
1854-1862
Publication date:
2012-10-15
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Language:
English
Keywords:
Pubs id:
pubs:350941
UUID:
uuid:65e596ef-20fc-418b-8b42-d9a310374a44
Local pid:
pubs:350941
Source identifiers:
350941
Deposit date:
2013-11-16

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