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Chronic stress in caregivers of dementia patients is associated with reduced lymphocyte sensitivity to glucocorticoids.

Abstract:

Caring for the chronically ill is associated with chronic distress. In view of the adverse effects of distress on cellular immune function, such distress may have implications for health. Indeed, it has been proposed that the hypothalamic-pituitary-adrenal (HPA) axis is a potential psychobiological mediator of these effects. In this study, we observed that elderly caregivers experienced greater distress and increased salivary cortisol than non-caregivers. In addition, caregivers had blunted m...

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Publication status:
Published

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Authors


Vedhara, K More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Lightman, SL More by this author
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Journal:
Journal of neuroimmunology
Volume:
103
Issue:
1
Pages:
84-92
Publication date:
2000-02-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:65e2551a-26e3-4d66-a35a-187c02f1a1b5
Source identifiers:
31624
Local pid:
pubs:31624

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