Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice.

Journal article

Macrophage scavenger receptors (MSR) promote atherosclerotic lesion formation, and modulation of MSR activity has been shown to influence atherosclerosis. Soluble receptors are effective in inhibiting receptor-mediated functions in various diseases. We have generated a secreted macrophage scavenger receptor (sMSR) that consists of the bovine growth hormone signal sequence and the human MSR A I extracellular domains. sMSR reduces degradation of atherogenic modified low-density lipoproteins and...

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Authors: Jalkanen, J; Leppänen, P; Pajusola, K; Närvänen, O; Mähönen, A

• Publication status: Published
• Journal: Molecular therapy : the journal of the American Society of Gene Therapy
• Volume: 8
• Issue: 6
• Pages: 903-910
• Publication date: 2003-12-01
• DOI: 10.1016/j.ymthe.2003.09.012
• EISSN: 1525-0024
• ISSN: 1525-0016
• Language: English
• Keywords: Receptors, Scavenger; Receptors, Immunologic; Dependovirus; Receptors, LDL; Humans; Arteriosclerosis; Genetic Therapy; Mice, Knockout; Aorta; Genetic Vectors; Animals; Lipids; Mice