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Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation

Abstract:

Anterior gradient 2 (AGR2) is a dimeric protein disulfide isomerase family member involved in the regulation of protein quality control in the endoplasmic reticulum (ER). Mouse AGR2 deletion increases intestinal inflammation and promotes the development of inflammatory bowel disease (IBD). Although these biological effects are well established, the underlying molecular mechanisms of AGR2 function toward inflammation remain poorly defined. Here, using a protein–protein interaction screen to id...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0003-3896-4270
Publisher:
Wiley Open Access
Journal:
EMBO Molecular Medicine More from this journal
Volume:
11
Issue:
6
Article number:
e10120
Publication date:
2019-04-30
Acceptance date:
2019-04-07
DOI:
EISSN:
1757-4684
ISSN:
1757-4676
Pmid:
31040128
Language:
English
Keywords:
Pubs id:
1050516
Local pid:
pubs:1050516
Deposit date:
2020-04-07

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