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α-Synuclein and dopamine at the crossroads of Parkinson's disease.

Abstract:

α-Synuclein is central to the Lewy body neuropathology of Parkinson's disease (PD), a devastating neurodegenerative disorder characterized by numerous motor and non-motor manifestations. The cardinal motor symptoms are linked to death of dopaminergic neurons in the nigrostriatal pathway. Here we ask why these neurons are preferentially susceptible to neurodegeneration in PD and how α-synuclein is involved. To address these questions we bring together recent findings from genome-wide associati...

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Publication status:
Published

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Publisher copy:
10.1016/j.tins.2010.09.004

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Trends in neurosciences
Volume:
33
Issue:
12
Pages:
559-568
Publication date:
2010-12-05
DOI:
EISSN:
1878-108X
ISSN:
0166-2236
URN:
uuid:65ddac0f-2b71-45de-8129-d440b65201d7
Source identifiers:
113396
Local pid:
pubs:113396

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