- Abstract:
-
SecY is the central channel protein of the SecYEbeta translocon, the structure of which has been determined by X-ray diffraction. Extended (15 ns) MD simulations of the isolated SecY protein in a phospholipid bilayer have been performed to explore the relationship between protein flexibility and the mechanisms of channel gating. In particular, principal components analysis of the simulation trajectory has been used to probe the intrinsic flexibility of the isolated SecY protein in the absence...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/bi061013d
-
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- Journal:
- Biochemistry
- Volume:
- 45
- Issue:
- 43
- Pages:
- 13018-13024
- Publication date:
- 2006-10-05
- DOI:
- EISSN:
-
1520-4995
- ISSN:
-
0006-2960
- URN:
-
uuid:65da7754-e194-4a8b-9cf8-0ace7ec83af3
- Source identifiers:
-
100451
- Local pid:
- pubs:100451
- Copyright date:
- 2006
Journal article
Simulations of a protein translocation pore: SecY.
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