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Simulations of a protein translocation pore: SecY.

Abstract:

SecY is the central channel protein of the SecYEbeta translocon, the structure of which has been determined by X-ray diffraction. Extended (15 ns) MD simulations of the isolated SecY protein in a phospholipid bilayer have been performed to explore the relationship between protein flexibility and the mechanisms of channel gating. In particular, principal components analysis of the simulation trajectory has been used to probe the intrinsic flexibility of the isolated SecY protein in the absence...

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Publication status:
Published

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Publisher copy:
10.1021/bi061013d

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Journal:
Biochemistry
Volume:
45
Issue:
43
Pages:
13018-13024
Publication date:
2006-10-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:65da7754-e194-4a8b-9cf8-0ace7ec83af3
Source identifiers:
100451
Local pid:
pubs:100451

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