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Single nucleotide polymorphisms in the toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine

Abstract:

The rate of decay of antibody concentration following serogroup C meningococcal (MenC) polysaccharide-protein conjugate vaccination varies between individuals. This depends partly on vaccination age but may be influenced by human genetics. We studied 721 single nucleotide polymorphisms (SNPs) across 131 candidate genes in a first cohort of 905 Caucasians (11 to 21 years old; mean time after vaccination, 4.9 years) and 30 SNPs across 17 genes in a replication study using 155 children, aged 6 t...

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Publisher copy:
10.1128/CVI.05379-11

Authors


Hennig, BJ More by this author
Perrett, KP More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Journal:
Clinical and Vaccine Immunology
Volume:
19
Issue:
3
Pages:
295-303
Publication date:
2012-03-05
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
URN:
uuid:65c989c8-8d27-469b-b038-c413542fa56f
Source identifiers:
342918
Local pid:
pubs:342918
Language:
English

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