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Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure

Abstract:

Cells, particularly mechano-sensitive musculoskeletal cells such as tenocytes, routinely encounter oxidative stress. Oxidative stress can not only stimulate tissue repair, but also cause damage leading to tissue degeneration. As diabetes is associated with increased oxidative damage as well as increased risk of tendon degeneration, the aim of this study was to determine if extracellular glucose levels alter the response of tendon cells to oxidative stress. Primary human tenocytes were culture...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/cddis.2014.52

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Publisher:
Nature Publishing Group
Journal:
Cell Death and Disease More from this journal
Volume:
5
Issue:
February 2014
Publication date:
2014-02-20
Acceptance date:
2013-12-02
DOI:
EISSN:
2041-4889
ISSN:
2041-4889
Keywords:
Pubs id:
pubs:634757
UUID:
uuid:65c87eb8-221c-40c9-b1b2-f579767d527e
Local pid:
pubs:634757
Source identifiers:
634757
Deposit date:
2016-07-21

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