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Lumefantrine and desbutyl-lumefantrine population pharmacokinetic-pharmacodynamic relationships in pregnant women with uncomplicated Plasmodium falciparum malaria on the Thailand-Myanmar border

Abstract:

Artemether-lumefantrine is the most widely used antimalarial artemisinin-based combination treatment. Recent studies have suggested that day 7 plasma concentrations of the potent metabolite desbutyl-lumefantrine correlate better with treatment outcomes than those of lumefantrine. Low cure rates have been reported in pregnant women with uncomplicated falciparum malaria treated with artemether-lumefantrine in northwest Thailand. A simultaneous pharmacokinetic drug-metabolite model was developed...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.00267-15

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Institution:
University of Oxford
Department:
Oxford, MSD, Tropical Medicine
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Hanpithakpong, W More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Tropical Medicine
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Wellcome Trust More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial agents and chemotherapy Journal website
Volume:
59
Issue:
10
Pages:
6375-6384
Publication date:
2015-10-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:65c73cda-5240-427b-b373-e081766de313
Source identifiers:
535498
Local pid:
pubs:535498
Language:
English

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