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Journal article

Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy ± cetuximab.

Abstract:

PURPOSE: To study the somatic molecular profile of the EGF receptor (EGFR) pathway in advanced colorectal cancer, its relationship to prognosis, the site of the primary and metastases, and response to cetuximab. EXPERIMENTAL DESIGN: We used Sequenom and Pyrosequencing for high-throughput somatic profiling of the EGFR pathway in 1,976 tumors from patients with advanced colorectal cancer from the COIN trial (oxaliplatin and fluoropyrimidine chemotherapy ± cetuximab). Correlations between mutati...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Idziaszczyk, S More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
19
Issue:
15
Pages:
4104-4113
Publication date:
2013-08-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:65c485fa-d4ef-4286-902c-e960592568dd
Source identifiers:
419386
Local pid:
pubs:419386

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