- Abstract:
-
PURPOSE: To study the somatic molecular profile of the EGF receptor (EGFR) pathway in advanced colorectal cancer, its relationship to prognosis, the site of the primary and metastases, and response to cetuximab. EXPERIMENTAL DESIGN: We used Sequenom and Pyrosequencing for high-throughput somatic profiling of the EGFR pathway in 1,976 tumors from patients with advanced colorectal cancer from the COIN trial (oxaliplatin and fluoropyrimidine chemotherapy ± cetuximab). Correlations between mutati...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1158/1078-0432.ccr-12-2581
-
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- Journal:
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Volume:
- 19
- Issue:
- 15
- Pages:
- 4104-4113
- Publication date:
- 2013-08-05
- DOI:
- EISSN:
-
1557-3265
- ISSN:
-
1078-0432
- URN:
-
uuid:65c485fa-d4ef-4286-902c-e960592568dd
- Source identifiers:
-
419386
- Local pid:
- pubs:419386
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Somatic profiling of the epidermal growth factor receptor pathway in tumors from patients with advanced colorectal cancer treated with chemotherapy ± cetuximab.
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