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Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling.

Abstract:

The 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases are a superfamily of enzymes that catalyse a wide range of reactions including hydroxylations, desaturations and oxidative ring closures. Recently, it has been discovered that they act as sensors in the hypoxic response in humans and other animals. Substrate oxidation is coupled to conversion of 2OG to succinate and carbon dioxide. Kinetic, spectroscopic and structural studies are consistent with a consensus mechanism in which ord...

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Publication status:
Published

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Publisher copy:
10.1098/rsta.2004.1540

Authors


Hewitson, KS More by this author
Granatino, N More by this author
Welford, RW More by this author
McDonough, MA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
Volume:
363
Issue:
1829
Pages:
807-828
Publication date:
2005-04-05
DOI:
EISSN:
1471-2962
ISSN:
1364-503X
URN:
uuid:65b4723d-10b8-462b-a261-4e8aa1aeb812
Source identifiers:
33104
Local pid:
pubs:33104

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