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Thesis

Integrated transcriptomic and proteomic profiling of responses to clinical and novel bisphosphonates

Abstract:

Bisphosphonates have traditionally been used to treat bone resorptive disorders by inhibiting osteoclast activity. Recent evidence, however, suggests their broader therapeutic effects beyond the skeleton. Clinical trials have revealed unexpected reductions in risk of multiple ageing related disease and all-cause mortality among osteoporotic patients treated with bisphosphonates. Pre-clinical studies also indicate that the observed non-skeletal effects of bisphosphonates are likely due to m...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Research group:
Muscoloskeletal Ageing
Oxford college:
St Cross College
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Role:
Supervisor
ORCID:
0000-0001-7391-0820
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Role:
Supervisor
ORCID:
0000-0003-1889-6530

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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