Measurement of circulating forms of prostate-specific antigen in whole blood immediately after venipuncture: implications for point-of-care testing.

Journal article

BACKGROUND: The purpose of this study was to validate the use of whole-blood samples in the determination of circulating forms of prostate-specific antigen (PSA). METHODS: Blood samples of hospitalized prostate cancer and benign prostatic hyperplasia patients were collected and processed to generate whole-blood and serum samples. Three different rapid two-site immunoassays were developed to measure the concentrations of total PSA (PSA-T), free PSA (PSA-F), and PSA-alpha(1)-antichymotrypsin co...

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Authors: Piironen, T; Nurmi, M; Irjala, K; Heinonen, O; Lilja, H

• Journal: Clinical chemistry
• Volume: 47
• Issue: 4
• Pages: 703-711
• Publication date: 2001-04-01
• EISSN: 1530-8561
• ISSN: 0009-9147
• Language: English
• Keywords: Male; Humans; Protein Binding; Prostatic Hyperplasia; Blood Specimen Collection; Prostatic Neoplasms; Prostate-Specific Antigen; Reproducibility of Results; Immunoassay; alpha 1-Antichymotrypsin; Exercise Test; Point-of-Care Systems