Journal article icon

Journal article

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

Abstract:
The dynamic methylation of histone lysyl residues plays an important role in biology by regulating transcription, maintaining genomic integrity, and by contributing to epigenetic effects. Here we describe a variety of inhibitor scaffolds that inhibit the human 2-oxoglutarate-dependent JMJD2 subfamily of histone demethylases. Combined with structural data, these chemical starting points will be useful to generate small-molecule probes to analyze the physiological roles of these enzymes in epigenetic signaling.

Actions


Authors


Expand authors...
Journal:
Journal of medicinal chemistry
Volume:
51
Issue:
22
Pages:
7053-7056
Publication date:
2008-01-01
ISSN:
1520-4804
URN:
uuid:6596571a-d090-4a3a-bb72-d26c1926eefd
Local pid:
SGC:18942826

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP