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The MITF-SOX10 regulated long non-coding RNA DIRC3 is a melanoma tumour suppressor

Abstract:

The MITF and SOX10 transcription factors regulate the expression of genes important for melanoma proliferation, invasion and metastasis. Despite growing evidence of the contribution of long noncoding RNAs (lncRNAs) in cancer, including melanoma, their functions within MITF-SOX10 transcriptional programmes remain poorly investigated. Here we identify 245 candidate melanoma associated lncRNAs whose loci are co-occupied by MITF-SOX10 and that are enriched at active enhancer-like regions. Our wor...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1008501

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
15
Issue:
12
Article number:
e1008501
Publication date:
2019-12-27
Acceptance date:
2019-12-06
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
1077606
Pubs id:
pubs:1077606
UUID:
uuid:6592b477-ee3f-436e-9119-3dc013505198
Local pid:
pubs:1077606
Deposit date:
2019-12-13

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