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The vacuolar pathway of long peptide cross-presentation can be TAP dependent

Abstract:

The intracellular pathway of cross-presentation, which allows MHC class I–restricted presentation of peptides derived from exogenous Ags, remains poorly defined and may vary with the nature of the exogenous Ag and the type of APC. It can be cytosolic, characterized by proteasome and TAP dependency, or vacuolar, usually believed to be proteasome and TAP independent. Cross-presentation is particularly effective with long synthetic peptides, and we previously reported that the HLA-A2–restricted ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1800353

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Role:
Author
ORCID:
0000-0002-0931-4044
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Role:
Author
ORCID:
0000-0001-6353-9538
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Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
202
Issue:
2
Pages:
451-459
Publication date:
2019-01-15
Acceptance date:
2018-11-12
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Pubs id:
pubs:953385
URN:
uri:658b3100-1505-43b3-ad32-c12f6c548ef7
UUID:
uuid:658b3100-1505-43b3-ad32-c12f6c548ef7
Local pid:
pubs:953385
Language:
English

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