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Evaluation of whole genome sequencing for Mycobacterial species identification and drug susceptibility testing in a clinical setting: a large-scale prospective assessment of performance against line-probe assays and phenotyping

Abstract:

Use of whole genome sequencing (WGS) for routine Mycobacterial species identification and drug susceptibility testing (DST) is becoming a reality. We compared performance of WGS and standard laboratory workflows prospectively, by parallel processing at a major Mycobacterial Reference Service over one year, for species identification, first-line Mycobacterium tuberculosis (TB) resistance prediction, and turnaround time. Of 2039 isolates with line-probe results for species identification, 74 (3...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/JCM.01480-17

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Del Ojo Elias, C More by this author
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Clinical Microbiology Journal website
Publication date:
2017-11-22
Acceptance date:
2017-11-10
DOI:
EISSN:
1098-660X
ISSN:
0095-1137
Pubs id:
pubs:745079
URN:
uri:658a92b8-219f-4e94-b161-8c6b54ea475c
UUID:
uuid:658a92b8-219f-4e94-b161-8c6b54ea475c
Local pid:
pubs:745079

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