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Receptor protein tyrosine phosphatase micro: measuring where to stick.

Abstract:

We review here recent results on the structure and function of a receptor protein tyrosine phosphatase, RPTPmicro. In addition to their intercellular catalytic domains which bear the phosphatase activity, the RPTPs are cell-surface-receptor-type molecules and in many cases have large extracellular regions. What role can these extracellular regions play in function? For RPTPmicro, the extracellular region is known to mediate homophilic adhesion. Sequence analysis indicates that it comprises si...

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Publication status:
Published

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Publisher copy:
10.1042/bst0360167

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Journal:
Biochemical Society transactions
Volume:
36
Issue:
Pt 2
Pages:
167-172
Publication date:
2008-04-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:6589c208-afca-46a3-a167-04191996418b
Source identifiers:
27674
Local pid:
pubs:27674

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