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Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus.

Abstract:

Ischaemic stroke is a complex disorder caused by a combination of genetic and environmental factors. Clinical and epidemiological studies have provided strong evidence for genetic influences in the development of human stroke and several mendelian traits featuring stroke have been described. The genetic analysis of the non-mendelian, common ischaemic stroke in humans is hindered by the late onset of the disease and the mode of inheritance, which is complex, polygenic and multifactorial. An im...

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Publication status:
Published

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Publisher copy:
10.1038/ng0897-364

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Journal:
Nature genetics
Volume:
16
Issue:
4
Pages:
364-367
Publication date:
1997-08-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:657ecd15-4821-433b-9986-8eefcbb1f874
Source identifiers:
8289
Local pid:
pubs:8289

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