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Model of a six immunoglobulin-like domain fragment of filamin A (16-21) built using residual dipolar couplings.

Abstract:

Filamins are actin-binding proteins that participate in a wide range of cell functions, including cell morphology, locomotion, membrane protein localization, and intracellular signaling. The three filamin isoforms found in humans, filamins A, B, and C, are highly homologous, and their roles are partly complementary. In addition to actin, filamins interact with dozens of other proteins that have roles as membrane receptors and channels, enzymes, signaling intermediates, and transcription facto...

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Publisher copy:
10.1021/ja2114882

Authors


Tossavainen, H More by this author
Koskela, O More by this author
Ylänne, J More by this author
Campbell, ID More by this author
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Journal:
Journal of the American Chemical Society
Volume:
134
Issue:
15
Pages:
6660-6672
Publication date:
2012-04-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:657897ae-0eba-4f36-8e95-7717bf31eacf
Source identifiers:
329972
Local pid:
pubs:329972

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