Model of a six immunoglobulin-like domain fragment of filamin A (16-21) built using residual dipolar couplings.

Journal article

Filamins are actin-binding proteins that participate in a wide range of cell functions, including cell morphology, locomotion, membrane protein localization, and intracellular signaling. The three filamin isoforms found in humans, filamins A, B, and C, are highly homologous, and their roles are partly complementary. In addition to actin, filamins interact with dozens of other proteins that have roles as membrane receptors and channels, enzymes, signaling intermediates, and transcription facto...

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Authors: Tossavainen, H; Koskela, O; Jiang, P; Ylänne, J; Campbell, I

• Journal: Journal of the American Chemical Society
• Volume: 134
• Issue: 15
• Pages: 6660-6672
• Publication date: 2012-04-01
• DOI: 10.1021/ja2114882
• EISSN: 1520-5126
• ISSN: 0002-7863
• Language: English
• Keywords: Humans; Models, Molecular; Crystallography, X-Ray; Protein Conformation; Contractile Proteins; Immunoglobulin Fragments; Filamins; Microfilament Proteins; Magnetic Resonance Spectroscopy