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The study of candidate sialometabolism genes and sialometabolism gene regulation in Haemophilus influenzae

Abstract:

Sialic acid (SA) is a known major virulence factor of Haemophilus influenza (Hi). This study aims to analyse the functions of some candidate sialometabolism genes, and to further our current understanding on the Hi sialometabolism gene regulation.

Two candidate sialometabolism genes (HI0227 and HI0148) and their adjacent ORFs (HI0228, HI0148.1 and HI0149) were studied. HI0148.1 and HI0149 are transcribed as a single gene in screened NTHi strains, and we refer to the combined ORF as ...

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Institution:
University of Oxford
Department:
Medical Sciences Division - Paediatrics,Department of - Paediatrics

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Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:656c6197-b37e-4fba-8544-fbcdd74b549d
Local pid:
ora:7844

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