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Slow-wave activity saturation and thalamocortical isolation during propofol anesthesia in humans.

Abstract:

The altered state of consciousness produced by general anesthetics is associated with a variety of changes in the brain's electrical activity. Under hyperpolarizing influences such as anesthetic drugs, cortical neurons oscillate at ~1 Hz, which is measurable as slow waves in the electroencephalogram (EEG). We have administered propofol anesthesia to 16 subjects and found that, after they had lost behavioral responsiveness (response to standard sensory stimuli), each individual's EEG slow-wave...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Science translational medicine
Volume:
5
Issue:
208
Pages:
208ra148
Publication date:
2013-10-05
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
URN:
uuid:65670dca-47de-4c8f-94f0-c557b6dd4c01
Source identifiers:
435754
Local pid:
pubs:435754

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