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Red cell deformability, splenic function and anaemia in thalassaemia.

Abstract:

Red cell deformability (RCD) was measured in 38 patients with alpha-thalassaemia and 48 patients with beta-thalassaemia, of whom 13 had undergone splenectomy. All splenectomized patients, but none of those with intact spleens, had very rigid erythrocytes with an elongation index <0.45 at a high shear stress of 30 Pa suggesting a splenic recognition threshold for removal of rigid red cells. At this shear stress RCD correlated strongly with the degree of anaemia in both the splenectomized (r...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
British journal of haematology
Volume:
105
Issue:
2
Pages:
505-508
Publication date:
1999-05-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:6564e65e-1db3-48e6-b450-9485adcb253a
Source identifiers:
31477
Local pid:
pubs:31477

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