Journal article
Different substrate specificities of the two ADPR binding sites in TRPM2 channels of Nematostella vectensis and the role of IDPR
- Abstract:
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NvTRPM2 (Nematostella vectensis Transient Receptor Potential Melastatin 2), the species variant of the human apoptosis-related cation channel hTRPM2, is gated by ADP-ribose (ADPR) independently of the C-terminal NUDT9H domain that mediates ADPR-directed gating in hTRPM2. The decisive binding site in NvTRPM2 is likely to be identical with the N-terminal ADPR binding pocket in zebra fish DrTRPM2. Our aim was a characterization of this binding site in NvTRPM2 with respect to its substrate specif...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.6MB)
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(Version of record, pdf, 131.4KB)
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- Publisher copy:
- 10.1038/s41598-019-41531-4
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Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Scientific reports Journal website
- Volume:
- 9
- Issue:
- 1
- Article number:
- 4985
- Publication date:
- 2019-03-21
- Acceptance date:
- 2019-03-11
- DOI:
- EISSN:
-
2045-2322
- Pmid:
-
30899048
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:985406
- UUID:
-
uuid:655383a2-750d-432b-bdc5-7681a1062daf
- Local pid:
- pubs:985406
- Source identifiers:
-
985406
- Deposit date:
- 2019-04-22
Terms of use
- Copyright holder:
- Kuhn, FJP et al
- Copyright date:
- 2019
- Notes:
- Copyright © 2019 The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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