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The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.

Abstract:

The positive transcription elongation factor b (P-TEFb) (CDK9/cyclin T (CycT)) promotes mRNA transcriptional elongation through phosphorylation of elongation repressors and RNA polymerase II. To understand the regulation of a transcriptional CDK by its cognate cyclin, we have determined the structures of the CDK9/CycT1 and free cyclin T2. There are distinct differences between CDK9/CycT1 and the cell cycle CDK CDK2/CycA manifested by a relative rotation of 26 degrees of CycT1 with respect to ...

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Publication status:
Published

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Publisher copy:
10.1038/emboj.2008.121

Authors


Troiani, S More by this author
Rusconi, L More by this author
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Journal:
The EMBO journal
Volume:
27
Issue:
13
Pages:
1907-1918
Publication date:
2008-07-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:65500a35-bff3-4199-8956-d8665eba43f9
Source identifiers:
34283
Local pid:
pubs:34283

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