Journal article
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
- Abstract:
-
The positive transcription elongation factor b (P-TEFb) (CDK9/cyclin T (CycT)) promotes mRNA transcriptional elongation through phosphorylation of elongation repressors and RNA polymerase II. To understand the regulation of a transcriptional CDK by its cognate cyclin, we have determined the structures of the CDK9/CycT1 and free cyclin T2. There are distinct differences between CDK9/CycT1 and the cell cycle CDK CDK2/CycA manifested by a relative rotation of 26 degrees of CycT1 with respect to ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/emboj.2008.121
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Authors
Bibliographic Details
- Journal:
- EMBO journal
- Volume:
- 27
- Issue:
- 13
- Pages:
- 1907-1918
- Publication date:
- 2008-07-01
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- Source identifiers:
-
34283
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:34283
- UUID:
-
uuid:65500a35-bff3-4199-8956-d8665eba43f9
- Local pid:
- pubs:34283
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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