- Abstract:
-
The positive transcription elongation factor b (P-TEFb) (CDK9/cyclin T (CycT)) promotes mRNA transcriptional elongation through phosphorylation of elongation repressors and RNA polymerase II. To understand the regulation of a transcriptional CDK by its cognate cyclin, we have determined the structures of the CDK9/CycT1 and free cyclin T2. There are distinct differences between CDK9/CycT1 and the cell cycle CDK CDK2/CycA manifested by a relative rotation of 26 degrees of CycT1 with respect to ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/emboj.2008.121
-
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- Journal:
- The EMBO journal
- Volume:
- 27
- Issue:
- 13
- Pages:
- 1907-1918
- Publication date:
- 2008-07-05
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- URN:
-
uuid:65500a35-bff3-4199-8956-d8665eba43f9
- Source identifiers:
-
34283
- Local pid:
- pubs:34283
- Copyright date:
- 2008
Journal article
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
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