Bisphosphonate use and risk of post-operative fracture among patients undergoing a total knee replacement for knee osteoarthritis: a propensity score analysis.

Journal article

SUMMARY: We have shown that patients with osteoarthritis are at increased risk of fracture after total knee replacement (TKR). We conducted a population-based cohort study to assess the effect of bisphosphonate use on their post-surgery fracture risk. Cox regression adjusted by propensity score suggested a 50-55% reduction in risk of fracture post-surgery. INTRODUCTION: Patients with osteoarthritis have a higher bone mass but similar or higher risk of fracture. We recently demonstrated that p...

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Authors: Prieto-Alhambra, D; Javaid, M; Judge, A; Maskell, J; Kiran, A

• Publication status: Published
• Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
• Volume: 22
• Issue: 5
• Pages: 1555-1571
• Publication date: 2011-05-01
• DOI: 10.1007/s00198-010-1368-1
• EISSN: 1433-2965
• ISSN: 0937-941X
• Language: English
• Keywords: Medication Adherence; Bone Density Conservation Agents; Bone Density; Male; Osteoarthritis, Knee; Osteoporotic Fractures; Drug Utilization; Epidemiologic Methods; Aged; Middle Aged; Spain; Arthroplasty, Replacement, Knee; Diphosphonates; Humans; Female