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Bisphosphonate use and risk of post-operative fracture among patients undergoing a total knee replacement for knee osteoarthritis: a propensity score analysis.

Abstract:

SUMMARY: We have shown that patients with osteoarthritis are at increased risk of fracture after total knee replacement (TKR). We conducted a population-based cohort study to assess the effect of bisphosphonate use on their post-surgery fracture risk. Cox regression adjusted by propensity score suggested a 50-55% reduction in risk of fracture post-surgery. INTRODUCTION: Patients with osteoarthritis have a higher bone mass but similar or higher risk of fracture. We recently demonstrated that p...

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Publication status:
Published

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Publisher copy:
10.1007/s00198-010-1368-1

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Maskell, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Volume:
22
Issue:
5
Pages:
1555-1571
Publication date:
2011-05-05
DOI:
EISSN:
1433-2965
ISSN:
0937-941X
URN:
uuid:654fc22d-8313-4b60-aa11-27fe681c5cf0
Source identifiers:
107380
Local pid:
pubs:107380

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