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Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency.

Abstract:

Most eukaryotic cell types use a common program to regulate the process of cell division. During mitosis, successful partitioning of the genetic material depends on spatially coordinated chromosome movement and cell cleavage. Here we characterize a zebrafish mutant, retsina (ret), that exhibits an erythroid-specific defect in cell division with marked dyserythropoiesis similar to human congenital dyserythropoietic anemia. Erythroblasts from ret fish show binuclearity and undergo apoptosis due...

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Publication status:
Published

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Publisher copy:
10.1038/ng1137

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Journal:
Nature genetics
Volume:
34
Issue:
1
Pages:
59-64
Publication date:
2003-05-01
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Source identifiers:
22216

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