Journal article icon

Journal article

CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue.

Abstract:

BACKGROUND: Mast cells release mediators upon stimulation that contribute to the pathogenesis of chronic airway disease, including the recruitment and activation of Th2 lymphocytes. The objective was to determine the involvement of prostaglandin D(2) (PGD(2)) and its receptors in the chemotaxis of Th2 cells, using nasal polyp tissue. METHODS: Tissue explants from ten patients with nasal polyposis were incubated with RPMI alone or RPMI containing IgE/anti-IgE for 30 min. Some samples were tre...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Expand authors...
Journal:
Allergy
Volume:
65
Issue:
3
Pages:
304-310
Publication date:
2010-03-05
DOI:
EISSN:
1398-9995
ISSN:
0105-4538
URN:
uuid:6548792b-45c2-4754-a8f7-a77f8f04c071
Source identifiers:
111651
Local pid:
pubs:111651

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP