Journal article
Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes
- Abstract:
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Mitochondrial tRNAs are transcribed as long polycistronic transcripts of precursor tRNAs and undergo posttranscriptional modifications such as endonucleolytic processing and methylation required for their correct structure and function. Among them, 5′-end processing and purine 9 N1-methylation of mitochondrial tRNA are catalyzed by two proteinaceous complexes with overlapping subunit composition. The Mg2+-dependent RNase P complex for 5′-end cleavage comprises the methyltransferase domain–con...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
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- Files:
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(pdf, 2.5MB)
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- Publisher copy:
- 10.1074/jbc.ra117.001286
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Authors
Funding
Fonds Brachet
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Fonds Van Buuren
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Action Medical Research
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Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Biological Chemistry Journal website
- Volume:
- 293
- Issue:
- 33
- Pages:
- 12862–12876
- Publication date:
- 2018-06-07
- Acceptance date:
- 2018-06-07
- DOI:
- EISSN:
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1083-351X
- ISSN:
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0021-9258
- Pubs id:
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pubs:857522
- URN:
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uri:652e0160-f8b1-4788-9590-e5d799947d92
- UUID:
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uuid:652e0160-f8b1-4788-9590-e5d799947d92
- Local pid:
- pubs:857522
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright holder:
- American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 by The American Society for Biochemistry and Molecular Biology, Inc.
Author's Choice—Final version free via Creative Commons CC-BY license.
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