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Journal article

Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and ribonuclease P complexes

Abstract:

Mitochondrial tRNAs are transcribed as long polycistronic transcripts of precursor tRNAs and undergo posttranscriptional modifications such as endonucleolytic processing and methylation required for their correct structure and function. Among them, 5′-end processing and purine 9 N1-methylation of mitochondrial tRNA are catalyzed by two proteinaceous complexes with overlapping subunit composition. The Mg2+-dependent RNase P complex for 5′-end cleavage comprises the methyltransferase domain–con...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1074/jbc.ra117.001286

Authors


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ORCID:
0000-0001-9525-7295
Roovers, M More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
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Fonds Brachet More from this funder
Fonds Van Buuren More from this funder
Action Medical Research More from this funder
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
293
Issue:
33
Pages:
12862–12876
Publication date:
2018-06-07
Acceptance date:
2018-06-07
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pubs id:
pubs:857522
URN:
uri:652e0160-f8b1-4788-9590-e5d799947d92
UUID:
uuid:652e0160-f8b1-4788-9590-e5d799947d92
Local pid:
pubs:857522

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