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Journal article

A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome.

Abstract:

The ubiquitin-proteasome pathway degrades the majority of proteins in mammalian cells and plays an essential role in the generation of antigenic peptides presented by major histocompatibility class I molecules. Proteasome inhibitors are of great interest as research tools and drug candidates. Most work on proteasome inhibitors has focused on the inhibition of the chymotryptic-like (beta5) sites; little attention has been paid to the inhibition of two other types of active sites, the trypsin-l...

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Publication status:
Published

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Publisher copy:
10.1016/j.bmcl.2007.03.092

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Journal:
Bioorganic and medicinal chemistry letters
Volume:
17
Issue:
12
Pages:
3402-3405
Publication date:
2007-06-05
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
URN:
uuid:652af5f8-e47f-4293-976b-2fa0bd06a0b1
Source identifiers:
5829
Local pid:
pubs:5829

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