Journal article icon

Journal article

A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome.

Abstract:

The ubiquitin-proteasome pathway degrades the majority of proteins in mammalian cells and plays an essential role in the generation of antigenic peptides presented by major histocompatibility class I molecules. Proteasome inhibitors are of great interest as research tools and drug candidates. Most work on proteasome inhibitors has focused on the inhibition of the chymotryptic-like (beta5) sites; little attention has been paid to the inhibition of two other types of active sites, the trypsin-l...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.bmcl.2007.03.092

Authors


van Swieten, PF More by this author
Hernández, RO More by this author
van den Nieuwendijk, AM More by this author
Leeuwenburgh, MA More by this author
Expand authors...
Journal:
Bioorganic and medicinal chemistry letters
Volume:
17
Issue:
12
Pages:
3402-3405
Publication date:
2007-06-05
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
URN:
uuid:652af5f8-e47f-4293-976b-2fa0bd06a0b1
Source identifiers:
5829
Local pid:
pubs:5829

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP