White matter hyperintensities in late life depression: a systematic review.

Journal article

BACKGROUND: White matter hyperintensities in MRI scans are age related but appear to be more prevalent in depressed patients. They may be more pronounced in late onset depression. This finding, if confirmed, would potentially illuminate the heterogeneity of depression in elderly subjects. METHODS: We conducted a systematic literature search of studies investigating white matter changes in late life depression, identifying 98 studies. The 30 remaining eligible studies were scrutinised for the ...

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Authors: Herrmann, L; Le Masurier, M; Ebmeier, K

• Publication status: Published
• Journal: Journal of neurology, neurosurgery, and psychiatry
• Volume: 79
• Issue: 6
• Pages: 619-624
• Publication date: 2008-06-01
• DOI: 10.1136/jnnp.2007.124651
• EISSN: 1468-330X
• ISSN: 0022-3050
• Language: English
• Keywords: Nerve Fibers, Myelinated; Humans; Middle Aged; Aged; Depressive Disorder, Major; Female; Cerebral Ventricles; Male; Magnetic Resonance Imaging; Depressive Disorder; Cerebrovascular Disorders; Brain; Age of Onset