Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?

Journal article

Liver fat represents a balance between input, secretion, and oxidation of fatty acids. As humans spend the majority of a 24-h period in a postprandial state, dietary fatty acids make an important contribution to liver fat metabolism. We compared hepatic fatty acid partitioning in healthy lean (n = 9) and abdominally obese (n = 10) males over 24 h. Volunteers received three mixed meals adjusted for basal metabolic rate. U-13C-labeled fatty acids were incorporated into the meals, and [2H2]palmi...

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Authors: Hodson, L; McQuaid, SE; Humphreys, S; Milne, R; Fielding, B

• Publication status: Published
• Journal: American journal of physiology. Endocrinology and metabolism
• Volume: 299
• Issue: 4
• Pages: E584-E592
• Publication date: 2010-10-01
• DOI: 10.1152/ajpendo.00272.2010
• EISSN: 1522-1555
• ISSN: 0193-1849
• Language: English
• Keywords: Apolipoproteins B; Adult; Fatty Liver; Obesity; Young Adult; Postprandial Period; Lipoproteins, VLDL; Middle Aged; Insulin; gamma-Glutamyltransferase; Lipoproteins; Humans; C-Reactive Protein; Fatty Acids, Nonesterified; Triglycerides; Dietary Fats; Alanine Transaminase; Male; Area Under Curve; 3-Hydroxybutyric Acid