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Sub-cellular targeting of constitutive NOS in health and disease

Abstract:

Constitutive nitric oxide synthases (NOSs) are ubiquitous enzymes that play a pivotal role in the regulation of myocardial function in health and disease. The discovery of both a neuronal NOS (nNOS) and an endothelial NOS (eNOS) isoform in the myocardium and the availability of genetically modified mice with selective eNOS or nNOS gene deletion have been of crucial importance for understanding the role of constitutive nitric oxide (NO) production in the myocardium. eNOS and nNOS are homologou...

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Publisher copy:
10.1016/j.yjmcc.2011.09.006

Authors


Journal:
Journal of Molecular and Cellular Cardiology
Volume:
52
Issue:
2
Pages:
341-350
Publication date:
2012-02-05
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
URN:
uuid:6511eef3-5bfe-4ebb-8b26-496f6515bbb9
Source identifiers:
313404
Local pid:
pubs:313404

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