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A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.

Abstract:

The influenza A virus RNA-dependent RNA polymerase consists of three subunits-PB1, PB2, and PA. The PB1 subunit is the catalytically active polymerase, catalyzing the sequential addition of nucleotides to the growing RNA chain. The PB2 subunit is a cap-binding protein that plays a role in initiation of viral mRNA synthesis by recruiting capped RNA primers. The function of PA is unknown, but previous studies of temperature-sensitive viruses with mutations in PA have implied a role in viral RNA...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Journal of virology
Volume:
76
Issue:
18
Pages:
8989-9001
Publication date:
2002-09-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
29363
Language:
English
Keywords:
Pubs id:
pubs:29363
UUID:
uuid:6505ee97-51f8-438a-8554-03694ff51a4b
Local pid:
pubs:29363
Deposit date:
2012-12-19

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