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A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.

Abstract:

The influenza A virus RNA-dependent RNA polymerase consists of three subunits-PB1, PB2, and PA. The PB1 subunit is the catalytically active polymerase, catalyzing the sequential addition of nucleotides to the growing RNA chain. The PB2 subunit is a cap-binding protein that plays a role in initiation of viral mRNA synthesis by recruiting capped RNA primers. The function of PA is unknown, but previous studies of temperature-sensitive viruses with mutations in PA have implied a role in viral RNA...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Mingay, LJ More by this author
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Journal:
Journal of virology
Volume:
76
Issue:
18
Pages:
8989-9001
Publication date:
2002-09-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:6505ee97-51f8-438a-8554-03694ff51a4b
Source identifiers:
29363
Local pid:
pubs:29363

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