- Abstract:
-
The influenza A virus RNA-dependent RNA polymerase consists of three subunits-PB1, PB2, and PA. The PB1 subunit is the catalytically active polymerase, catalyzing the sequential addition of nucleotides to the growing RNA chain. The PB2 subunit is a cap-binding protein that plays a role in initiation of viral mRNA synthesis by recruiting capped RNA primers. The function of PA is unknown, but previous studies of temperature-sensitive viruses with mutations in PA have implied a role in viral RNA...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/jvi.76.18.8989-9001.2002
-
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- Journal:
- Journal of virology
- Volume:
- 76
- Issue:
- 18
- Pages:
- 8989-9001
- Publication date:
- 2002-09-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:6505ee97-51f8-438a-8554-03694ff51a4b
- Source identifiers:
-
29363
- Local pid:
- pubs:29363
- Copyright date:
- 2002
Journal article
A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs.
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