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5-Fluoroindole-3-acetic acid: a prodrug activated by a peroxidase with potential for use in targeted cancer therapy.

Abstract:

Indole-3-acetic acid and some derivatives are oxidized by horseradish peroxidase, forming a radical-cation that rapidly fragments (eliminating CO(2)) to form cytotoxic products. No toxicity is seen when either indole-3-acetic acid or horseradish peroxidase is incubated alone at concentrations that together form potent cytotoxins. Unexpectedly, 5-fluoroindole-3-acetic acid, which is oxidized by horseradish peroxidase compound I 10-fold more slowly than indole-3-acetic acid, is much more cytoto...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Stratford, MR More by this author
Wardman, P More by this author
Journal:
Biochemical pharmacology
Volume:
63
Issue:
2
Pages:
265-272
Publication date:
2002-01-05
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
URN:
uuid:64fc7011-4b29-4fec-81dd-9486cbd4df89
Source identifiers:
131576
Local pid:
pubs:131576

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