We have identified Ngef as a novel member of the family of Dbl genes. Many members of this family have been shown to function as guanine nucleotide exchange factors for the Rho-type GTPases. Ngef is predominantly expressed in brain, with the strongest signal in the caudate nucleus, a region associated with the control of movement. Ngef contains a translated trinucleotide repeat, a polyglutamic acid stretch interrupted by a glycine. We have localized the Ngef gene to mouse chromosome 1 and the...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Characterization of Ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus.
If you are the owner of this record, you can report an update to it here: Report update to this record