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Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination.

Abstract:

We present a molecular dissection of pause site-dependent transcriptional termination for mammalian RNA polymerase II (Pol II)-transcribed genes. We show that nascent transcripts form RNA/DNA hybrid structures (R-loops) behind elongating Pol II and are especially prevalent over G-rich pause sites positioned downstream of gene poly(A) signals. Senataxin, a helicase protein associated with AOA2/ALS4 neurodegenerative disorders, acts to resolve these R-loop structures and by so doing allows acce...

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Publication status:
Published

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Authors


Skourti-Stathaki, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Molecular cell
Volume:
42
Issue:
6
Pages:
794-805
Publication date:
2011-06-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:64f2b640-f129-4b53-b99a-325e61a1e78e
Source identifiers:
163916
Local pid:
pubs:163916

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