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Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages.

Abstract:

Understanding the signalling mechanisms controlling inflammatory cytokine production is pivotal to the research of both acute and chronic immune disorders. Tyrosine phosphorylation is one of the earliest events to occur in response to an immune challenge yet the role of specific tyrosine kinases in inflammatory cytokine production has been difficult to ascribe due to conflicting literature. Here we show that the pyrazolo pyrimidine compound PP2, a selective inhibitor of Src family kinases (SF...

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Publication status:
Published

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Authors


Smolinska, MJ More by this author
Horwood, NJ More by this author
Smallie, T More by this author
Foxwell, BM More by this author
Journal:
Molecular immunology
Volume:
45
Issue:
4
Pages:
990-1000
Publication date:
2008-02-05
DOI:
EISSN:
1872-9142
ISSN:
0161-5890
URN:
uuid:64f1aa70-5971-4b4a-ad59-af1483a21247
Source identifiers:
223515
Local pid:
pubs:223515

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